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Read More Chanarin-Dorfman Syndrome: The Enormous Value of a Simple Peripheral Blood Smears in Ichthyosis Saving Time & Money

Chanarin-Dorfman Syndrome: The Enormous Value of a Simple Peripheral Blood Smears in Ichthyosis Saving Time & Money

Abstract: Chanarin-Dorfman syndrome (CDS) is a rare nonlysosomal autosomal recessive neutrophil lipid storage disorder characterized by deposition of cytoplasmic neutral lipid droplets in many cell types. It is clinically characterized by nonbullous congenital ichthyosiform erythroderma, hepatomegaly, myopathy, ataxia, neurosensory hearing loss and varying developmental delay. A peripheral blood smear showing lipid droplets in granulocytes is …

Read More Hyaluronic Acid

Hyaluronic Acid

Hyaluronic acid – the name reflects its glassy appearance (the greek word for glass is hyalos) and the presence of sugar known as uronic acid. Introduction H.A. also called hyaluronan is anionic, nonsulfated glycosaminoglycan distributed widely throughout connecting, epithilian and neural tissues. The average 70kg person has roughly 15gms of H.A. in the body, one-third …

Read More Polypodium Leucotomos: The latest Oral Sunscreen on The Block

Polypodium Leucotomos: The latest Oral Sunscreen on The Block

The pathogenetic role of UV radiation in phototoxic reactions and photoallergic dermatoses such as polymorphous light eruption (PMLE) has now become axiomatic. While sun-induced acute sunburn,melanomas, and nonmelanoma skin cancers (NMSC) are the primary concerns of people with Fitzpatrick skin Types I–III, the darker ethnic population ought to have effective sun protection as well, primarily for the prevention and …

Read More Thread Lift – An Emerging Trend

Thread Lift – An Emerging Trend

This is what I read on the internet some other day. Today this applies to men as well as women as both seem to have been bitten by “look your best” bug. Ageing and fat (specially the sudden loss of fat), are responsible for sagging skin. Gravity and pregnancy also contribute to further sagging of …

Read More Venous Leg Ulcers: Understanding The Pathogenesis And Management Principles

Venous Leg Ulcers: Understanding The Pathogenesis And Management Principles

Chronic leg ulcers can be defined as any ulcer on the lower leg (excluding those on the forefoot or toes) lasting for more than six weeks with no tendency of healing after three months or more.Among the various etiological factors leading to leg ulcers, venous disease is responsible for 60-70% of the cases and the …

Read More Finally, A Non Invasive Treatment For Chin Fat, Or “Double Chin” – Kybella (Deoxycholic Acid): A Review

Finally, A Non Invasive Treatment For Chin Fat, Or “Double Chin” – Kybella (Deoxycholic Acid): A Review

Chemical structure of Deoxycholic acid: Mechanism Of Action: —Deoxycholic acid is an endogenous bile acid that solubilizes dietary fat in the gut.1 Kybella contains synthetically derived deoxycholic acid. When the drug is injected into subcutaneous fat tissue, it solubilizes lipids in adipocyte membranes. The resulting cytolysis induces an inflammatory response that clears cell debris.2. Clinical Studies: — Approval …

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